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Caspase-6重組兔單克隆抗體

產(chǎn)品貨號：

BN42138R
中文名稱：

Caspase-6重組兔單克隆抗體
英文名稱：

Rabbit anti-Caspase-6 Monoclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規(guī)格

售價

備注
BN42138R-50ul

50ul

￥2020.00

交叉反應：Human,Mouse,Rat 推薦應用：WB,IHC-P,IHC-F,ICC,IF
BN42138R-100ul

100ul

￥3240.00

交叉反應：Human,Mouse,Rat 推薦應用：WB,IHC-P,IHC-F,ICC,IF

產(chǎn)品描述

英文名稱	Caspase-6
中文名稱	Caspase-6重組兔單克隆抗體
別名	Apoptosis-related cysteine protein; Apoptosis Related Cysteine Protease; Apoptotic cysteine protease MCH2; Apoptotic protease MCH 2; Apoptotic protease MCH2; Casp 6; Casp6; Caspase 6 apoptosis related cysteine protease; Caspase 6 precursor; Caspase6; Human cysteine protease Mch2 isoform alpha; Mch 2; Mch2; CASP6_HUMAN.
研究領域	細胞生物細胞凋亡
抗體來源	Rabbit
克隆類型	Monoclonal
克隆號	10F5
交叉反應	Human, Mouse, Rat,
產(chǎn)品應用	WB=1:1000-2000 IP=1:10-50 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	33kDa
細胞定位	細胞核細胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Caspase-6:
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008] Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. Subunit: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. Subcellular Location: Cytoplasm. Post-translational modifications: Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits. Similarity: Belongs to the peptidase C14A family. SWISS: P55212 Gene ID: 839 Database links: Entrez Gene: 839 Human Entrez Gene: 12368 Mouse Entrez Gene: 83584 Rat Omim: 601532 Human SwissProt: P55212 Human SwissProt: O08738 Mouse SwissProt: O35397 Rat Unigene: 654616 Human Unigene: 281379 Mouse Unigene: 88160 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.