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RAB27A蛋白單克隆抗體

產(chǎn)品貨號：

BN42064M
中文名稱：

RAB27A蛋白單克隆抗體
英文名稱：

Mouse anti-RAB27A Monoclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規(guī)格

售價

備注
BN42064M-50ul

50ul

￥2020.00

交叉反應(yīng)：Human 推薦應(yīng)用：WB,Flow-Cyt
BN42064M-100ul

100ul

￥3240.00

交叉反應(yīng)：Human 推薦應(yīng)用：WB,Flow-Cyt

產(chǎn)品描述

英文名稱	RAB27A
中文名稱	RAB27A蛋白單克隆抗體
別名	GS2; GTP-binding protein Ram; HsT18676; MGC117246; Rab-27; RAB-27A; RAB27; RAB27A; RAB27A member RAS oncogene family; RAM; Ras-related protein Rab-27A; Ras-related protein Rab27A; RB27A_HUMAN.
研究領(lǐng)域	腫瘤細(xì)胞生物轉(zhuǎn)錄調(diào)節(jié)因子合成與降解轉(zhuǎn)運蛋白
抗體來源	Mouse
克隆類型	Monoclonal
克隆號	9C6
交叉反應(yīng)	Human,
產(chǎn)品應(yīng)用	WB=1:500-2000 ELISA=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	25kDa
細(xì)胞定位	細(xì)胞漿細(xì)胞膜
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human RAB27A:
亞型	IgG1
純化方法	affinity purified by Protein G
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq]. Function: Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Subunit: Binds SYTL1, SLAC2B, MYRIP, SYTL3, SYTL4 and SYTL5 (By similarity). Binds MLPH and SYTL2. Interacts with UNC13D. Subcellular Location: Membrane; Lipid-anchor. Melanosome. Late endosome. Lysosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes to endosomal exocytic vesicles. Tissue Specificity: Found in all the examined tissues except in brain. Low expression was found in thymus, kidney, muscle and placenta. Detected in melanocytes, and in most tumor cell lines examined. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells. DISEASE: Griscelli syndrome 2 (GS2) [MIM:607624]: Rare autosomal recessive disorder that results in pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes. GS2 patients also develop an uncontrolled T-lymphocyte and macrophage activation syndrome, known as hemophagocytic syndrome, leading to death in the absence of bone marrow transplantation. Neurological impairment is present in some patients, likely as a result of hemophagocytic syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the small GTPase superfamily. Rab family. SWISS: P51159 Gene ID: 5873 Database links: Entrez Gene: 5873 Human Entrez Gene: 11891 Mouse Entrez Gene: 50645 Rat Omim: 603868 Human SwissProt: P51159 Human SwissProt: Q9ERI2 Mouse SwissProt: P23640 Rat Unigene: 654978 Human Unigene: 480676 Mouse Unigene: 37360 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.