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產(chǎn)品規(guī)格
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BN40286R-100ul
100ul
￥2360.00
交叉反應：Human(predicted:Mouse,Rat,Chicken,Dog,Rabbit) 推薦應用：IHC-P,IHC-F,ICC,IF,ELISA
BN40286R-200ul
200ul
￥3490.00
交叉反應：Human(predicted:Mouse,Rat,Chicken,Dog,Rabbit) 推薦應用：IHC-P,IHC-F,ICC,IF,ELISA
產(chǎn)品描述
| 英文名稱 | Rho B |
| 中文名稱 | RhoB蛋白抗體 |
| 別 名 | Rh -related GTP binding protein RhoB; Rh -related GTP binding protein RhoC; RHOH6; Transforming protein RhoA; AA017882 antibody Aplysia ras related homolog 9 (RhoC); ARH9; ARHA; ARHB; ARHC; H6; MST081; MSTP08; Oncogene RHO H9; rhoC GTPase; Ras homolog 9 (RhoC); Ras homolog gene family, member A; Ras homolog gene family, member B; Ras homolog gene family, member C; Rho related GTP binding protein RhoC; RHO12; RHOB; RHOC; RHOH9; RP11-426L16.4; Small GTP binding protein RhoC; H9; Rho related GTP binding protein RhoB; ARH12; ARH6; H12.RHOB_HUMAN |
| 研究領域 | 細胞生物 信號轉導 激酶和磷酸酶 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human, (predicted: Mouse, Rat, Chicken, Dog, Rabbit, ) |
| 產(chǎn)品應用 | ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 22kDa |
| 細胞定位 | 細胞核 細胞漿 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Rho B:101-196/196 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | The Rho proteins interact directly with protein kinases which are likely to serve as downstream effector targets of the activated GTPase. The Rho family of GTPases are involved in the regulation of the actin skeleton. Activation of Rho to the GTP bound state promotes formation of stress fibers and is required for the formation and maintenance of focal adhesions. Pathways stimulated by cytokines, hormones and various forms of stress utilize p21 proteins of the Rho family. Possible mediators for these responses include protein kinase such as p120PKN, and p150 ROKa/Rho-A kinase, myosin light chain (MLC) phosphatase and PIP 5-kinase. Function: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells. Subunit: Binds ROCK1 and ROCK2. Also binds PKN1/PRK1. Interacts with ARGGEF3, RTKN and AKAP13. Subcellular Location: Rho A: Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm; cytoskeleton. Rho B: Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Rho C: Cell membrane; Lipid-anchor; Cytoplasmic side. Post-translational modifications: Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane while the geranylgeranylated form is localized to the endosome. Similarity: Belongs to the small GTPase superfamily. Rho family. SWISS: P62745 Gene ID: 388 Database links: Entrez Gene: 395734 Chicken Entrez Gene: 388 Human Entrez Gene: 11852 Mouse Omim: 165370 Human SwissProt: P62745 Human SwissProt: P62746 Mouse Unigene: 502876 Human Unigene: 687 Mouse Unigene: 2042 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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